Basic Information

IDDRAMP03125
SequenceATCDLASKWNWNHTLCAAHCIARRYRGGYCNSKAVCVCR
Length39
NameDef-DAA (hybrid defensins; Insects, animals)
SourceAnopheles gambiae (African malaria mosquito)
ActivityAntimicrobial, Antibacterial, Anti-Gram+
PathogenGram-positive bacteria: Staphylococcus aureus strain 21 (IC90=0.75 µg/mL), Staphylococcus aureus strain 4 (IC90=1.5 µg/mL).##T1=8 mg/kg, T2=30 mg/kg.##T1, dose causing the first signs of toxicity on mice. T2, lethal dose.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q17027
PDB 2E3G
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID18214975

Physicochemical Properties

Residues39
SequenceATCDLASKWNWNHTLCAAHCIARRYRGGYCNSKAVCVCR
Molecular Weight4403.067
Grand Average of Hydropathy-0.208
Isoelectric Point9.153
Charge at pH 7.44.524
Secondary StructureHelix: 0.231, Turn: 0.179, Sheet: 0.205
Instability Index19.536
Aromaticity0.103

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