Basic Information
| ID | DRAMP03173 |
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| Sequence | RWCVYAYVRVRGVLVRYRRCW |
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| Length | 21 |
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| Name | Arenicin-1 (Ar-1; marine polychaeta, animals) |
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| Source | Arenicola marina (Lugworm) (Lumbricus marinus) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Cytotoxic |
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| Pathogen | Gram-positive bacterium: Listeria monocytogenes EGD (MIC=0.6 µg/ml);##Gram-negative bacteria: Escherichia coli ML-35p (MIC=4 µg/ml), E. coli WBB01 (MIC=0.3 mM), E. coli ATCC 23716 (MIC=0.6 mM), Salmonella enterica R595 (MIC=0.3 mM), S. enterica R60 (MIC=1.25 mM), Proteus mirabilis R45 (MIC=0.6 mM).##Yeast: Candida albicans 820 (MIC=20 µg/ml).##Human Jurkat T-cells: LD50>40 mM (35.5% lysis at 30 mM). |
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| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
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| Cytotoxicity | [Ref.27940358] Cytotoxicity: human embryonic fibroblasts (HEF) and human red blood cells (hRBC)(IC50 for arenicin-1 in the presence or absence of 10% FBS were of 35 and 8 μM,HC50 indicating 50% hemolysis after 24 h incubation, equaled to 16μM). |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
Q5SC60, P84105 |
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| PDB |
2JSB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 15527787, 17935487 |
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