Basic Information

IDDRAMP03176
SequenceSWLSKTAKKLENSAKKRISEGIAIAIQGGPR
Length31
NameCecropin-P1 (CP1; nematodes, animals)
SourceAscaris suum (Pig roundworm) (Ascaris lumbricoides)
ActivityAntimicrobial, Antibacterial, Antifungal
PathogenP1-NH2 (amidated cecropin P1): [E. coli K-12/ D21 (MIC=0.3 µM), E. coli 853/67/0149/K88 (MIC=0.9 µM), E. coli Bd2221/75/08/K88 (MIC=0.6 µM), E. coli Bd4462/84/0101/K99 (MIC=0.7 µM), E. coli Bd4466/84/064/K99 (MIC=0.3 µM), Salmonella typhimurium LT2 (MIC=0.9 µM), A. calcoaceticus Ac1l (MIC=0.2 µM), Proteus vulgaris Pvll (MIC=5.7 µM), Pseudomonas aeruginosa OT97 (MIC=5.9 µM), Bacillus megaterium Bmll (MIC=1.8 µM), Streptococcus pyogenes (MIC=19 µM)].##P1-OH (non-amidated cecropin P1): [E. coli K-12/ D21 (MIC=0.4 µM), E. coli 853/67/0149/K88 (MIC=0.6 µM), E. coli Bd2221/75/08/K88 (MIC=0.7 µM), E. coli Bd4462/84/0101/K99 (MIC=0.8 µM), E. coli Bd4466/84/064/K99 (MIC=0.6 µM), Salmonella typhimurium LT2 (MIC=1.7 µM), A. calcoaceticus Ac1l (MIC=0.5 µM), Proteus vulgaris Pvll (MIC=12 µM), Pseudomonas aeruginosa OT97 (MIC=13 µM), Bacillus megaterium Bmll (MIC=5.3 µM), Streptococcus pyogenes (MIC=44 µM)].
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P14661, Q5H7N7
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID15850460, 1396696

Physicochemical Properties

Residues31
SequenceSWLSKTAKKLENSAKKRISEGIAIAIQGGPR
Molecular Weight3338.857
Grand Average of Hydropathy-0.558
Isoelectric Point10.565
Charge at pH 7.44.243
Secondary StructureHelix: 0.226, Turn: 0.290, Sheet: 0.258
Instability Index26.458
Aromaticity0.032

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Candidates based on structure

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