Basic Information

IDDRAMP03229
SequenceSWKSMAKKLKEYMEKLKQRA
Length20
NameM-zodatoxin-Lt3a (M-ZDTX-Lt3a; Latarcin-3a, Ltc-3a; spiders, Arthropods, animals)
SourceLachesana tarabaevi (Spider)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 µM), Bacillus subtilis VKM B-501 MIC=1.2 µM);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=2.5 µM), Escherichia coli MH1 (MIC=6.0 µM), Pseudomonas aeruginosa PAO1 (MIC>40 µM);##Fungi: Pichia pastoris GS115 (MIC=20 µM), Saccharomyces cerevisiae Y190 (MIC=20 µM).
Hemolytic Activity[Ref.16735513]20% hemolytic activity at >120 μM against rabbit erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q1ELU3
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16735513

Physicochemical Properties

Residues20
SequenceSWKSMAKKLKEYMEKLKQRA
Molecular Weight2483.993
Grand Average of Hydropathy-1.36
Isoelectric Point10.122
Charge at pH 7.44.238
Secondary StructureHelix: 0.200, Turn: 0.100, Sheet: 0.400
Instability Index32.48
Aromaticity0.1

Similar Structure Search

Candidates based on structure

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