Basic Information

IDDRAMP03230
SequenceSWASMAKKLKEYMEKLKQRA
Length20
NameM-zodatoxin-Lt3b (M-ZDTX-Lt3b; Latarcin-3b, Ltc-3b; spiders, Arthropods, animals)
SourceLachesana tarabaevi (Spider)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.7 µM), Bacillus subtilis VKM B-501 (MIC=2.9 µM);Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=23 µM), Escherichia coli MH1 (MIC=28 µM), Pseudomonas aeruginosa PAO1 (MIC>45 µM);##Fungi: Pichia pastoris GS115 (MIC=23 µM), Saccharomyces cerevisiae Y190 (MIC=23 µM).
Hemolytic Activity[Ref.16735513]20% hemolytic activity at >120 μM against rabbit erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q1ELU2
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16735513

Physicochemical Properties

Residues20
SequenceSWASMAKKLKEYMEKLKQRA
Molecular Weight2426.898
Grand Average of Hydropathy-1.075
Isoelectric Point9.997
Charge at pH 7.43.24
Secondary StructureHelix: 0.200, Turn: 0.100, Sheet: 0.450
Instability Index24.965
Aromaticity0.1

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