Basic Information

IDDRAMP03231
SequenceGLKDKFKSMGEKLKQYIQTWKAKF
Length24
NameM-zodatoxin-Lt4a (M-ZDTX-Lt4a; Latarcin-4a, Ltc-4a; spiders, Arthropods, animals)
SourceLachesana tarabaevi (Spider)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.16735513]Gram-positive bacteria: Arthrobacter globiformis VKM Ac-1112 (MIC=0.3 µM), Bacillus subtilis VKM B-501 (MIC=1.1 µM);##Gram-negative bacteria: Escherichia coli DH5-alpha (MIC=4.5 µM), Escherichia coli MH1 (MIC=3.2 µM), Pseudomonas aeruginosa PAO1 (MIC>35 µM);##Fungi: Pichia pastoris GS115 (MIC=36 µM), Saccharomyces cerevisiae Y190 (MIC=18 µM).
Hemolytic Activity[Ref.16735513]20% hemolytic activity at >120 μM against rabbit erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q1ELU5
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16735513

Physicochemical Properties

Residues24
SequenceGLKDKFKSMGEKLKQYIQTWKAKF
Molecular Weight2903.442
Grand Average of Hydropathy-1.017
Isoelectric Point10.001
Charge at pH 7.44.539
Secondary StructureHelix: 0.292, Turn: 0.125, Sheet: 0.208
Instability Index-13.525
Aromaticity0.167

Similar Structure Search

Candidates based on structure

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