Basic Information

IDDRAMP03311
SequenceRGFRKHFNKLVKKVKHTISETAHVAKDTAVIAGSGAAVVAAT
Length42
NameStomoxyn (Insects, animals)
SourceStomoxys calcitrans (Stable fly)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.12372834]Gram-negative bacteria: Escherichia coli K12 RM148 (MIC=0.19-0.39 µM), E. coli D22 (MIC=0.19-0.39 µM), E. coli D31(MIC=0.19-0.39 µM), E. coli SBS363 (MIC<0.19 µM), E. coli 1106 (MIC=0.19-0.39 µM), Enterobacter cloacae b12 (MIC=3.12-6.25 µM), Erwinia carotovora (MIC=0.78-1.56 µM), Klebsiella pneumoniae (MIC=0.78-1.56 µM), Pseudomonas aeruginosa (MIC=0.39-0.78 µM), Salmonella typhimurium (MIC=0.39-0.78 µM), Xanthomonas campestris ( MIC=0.39-0.78 µM);##Gram-positive bacteria: Aerococcus viridans (MIC=0.78-1.56 µM), Bacillus megaterium (MIC=0.78-1.56 µM), Bacillus subtilis (MIC=6.25-12.5 µM), Enterococcus faecalis (MIC=0.78-1.56 µM), Micrococcus luteus (MIC=0.78-1.56 µM), Streptococcus pyogenes (MIC=1.56-3.12 µM);##Fungi: Aspergillus fumigatus (MIC=50-100 µM), Fusarium culmorum (MIC=0.39-0.78 µM), Fusarium oxysporum (MIC=0.78-1.56 µM), Nectria haematococca (MIC=0.39-0.78 µM), N. crassa (MIC=3.12-6.25 µM), Trichoderma viride (MIC=1.56-3.12 µM), Trichophyton mentagrophytes (MIC=3.12-6.25 µM), Candida albicans (MIC=25-50 µM), C. glabrata (MIC=25-50 µM), C. neoformans (MIC=0.78-1.56 µM).
Hemolytic Activity[Ref.12372834]2% hemolytic activity at 10 μM, 9% hemolytic activity at 100 μM against bovine red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q8T9R8
PDB 1ZRX
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12372834, 16170803

Physicochemical Properties

Residues42
SequenceRGFRKHFNKLVKKVKHTISETAHVAKDTAVIAGSGAAVVAAT
Molecular Weight4416.096
Grand Average of Hydropathy-0.002
Isoelectric Point10.656
Charge at pH 7.45.654
Secondary StructureHelix: 0.262, Turn: 0.143, Sheet: 0.238
Instability Index0.664
Aromaticity0.048

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