Basic Information

IDDRAMP03565
SequenceDTHFPICIFCCGCCHRSKCGMCCKT
Length25
NameHuman hepcidin-25 (Hepc25; one chain of Hepcidin; Human, mammals, animals)
SourceHomo sapiens (Human)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli;##Gram-positive bacteria: Staphylococcus aureus, S. epidermidis, group B Streptococcus.##Fungi: Candida albicans, Aspergillus fumigatus, Aspergillus niger.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P81172, Q1HE14, Q9BY68
PDB 1M4F, 2KEF ##3H0T resolved by X-ray.
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11034317, 11113131, 12138110, 19553669

Physicochemical Properties

Residues25
SequenceDTHFPICIFCCGCCHRSKCGMCCKT
Molecular Weight2797.416
Grand Average of Hydropathy0.388
Isoelectric Point8.22
Charge at pH 7.41.43
Secondary StructureHelix: 0.160, Turn: 0.160, Sheet: 0.040
Instability Index37.76
Aromaticity0.08

Similar Structure Search

Candidates based on structure

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