Basic Information

IDDRAMP03585
SequenceAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDES
Length68
NameHuman TC-1 (Chain of Platelet basic protein; Human, mammals, animals)
SourceHomo sapiens (Human)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Bacillus subtilis (MBC=0.4 µM), Staphylococcus aureus (MBC=6.8 µM);##Gram-negative bacterium: Escherichia coli (MBC=3.4 µM).##Fungi: Cryptococcus neoformans (MFC=1.9 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P02775, B2R5F3, Q6IBJ8
PDB 1TVX resolved by X-ray.
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10877842, 8034022

Physicochemical Properties

Residues68
SequenceAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDES
Molecular Weight7441.702
Grand Average of Hydropathy-0.318
Isoelectric Point9.052
Charge at pH 7.43.567
Secondary StructureHelix: 0.250, Turn: 0.191, Sheet: 0.206
Instability Index22.122
Aromaticity0

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.