Basic Information

IDDRAMP03586
SequenceNLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDES
Length83
NameHuman TC-2 (Chain of Platelet basic protein; Human, mammals, animals)
SourceHomo sapiens (Human)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Bacillus subtilis ATCC6633 (MBC=0.7 µM), Staphylococcus aureus 42D (MBC=11 µM);##Gram-negative bacterium: Escherichia coli ML35 (MBC=2.7 µM).##Fungi: Cryptococcus neoformans (MFC=30 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P02775, B2R5F3, Q6IBJ8
PDB 1F9P resolved by X-ray.
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10877842, 8034022

Physicochemical Properties

Residues83
SequenceNLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDES
Molecular Weight9105.481
Grand Average of Hydropathy-0.446
Isoelectric Point8.409
Charge at pH 7.41.512
Secondary StructureHelix: 0.253, Turn: 0.205, Sheet: 0.241
Instability Index29.307
Aromaticity0.012

Similar Structure Search

Candidates based on structure

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