Basic Information
| ID | DRAMP03596 |
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| Sequence | AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL |
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| Length | 32 |
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| Name | Human defensin-6 (HD-6; Defensin, alpha 6; Human, mammals, animals) |
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| Source | Homo sapiens (Human) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2) |
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| Pathogen | [Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(HD6 only blocked SARS-CoV-2 infection at the highest concentration tested (50 μg/mL, 13 μM)).##Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50>256 µg/ml), E. coli ATCC 25922 (vLD50=103±14 µg/ml), Enterobacter aerogenes ATCC 13048 (vLD50=156±11 µg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50>256 µg/ml), S. aureus ATCC 29213 (vLD50>256 µg/ml), Bacillus cereus ATCC 10876 (vLD50=25±13 µg/ml).(Ref.3)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s). |
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| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
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| Cytotoxicity | [Ref.34206990]No cytotoxicity on HEK293T cells up to 50 μg/mL. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
Q01524 |
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| PDB |
1ZMQ, 3QTE resolved by X-ray. |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 34206990, 8417977, 17088326, 15616305 |
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