Basic Information

IDDRAMP03411
SequenceVTCFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ
Length33
NameNeutrophil defensin 4 (HANP-4; alpha-defensin; Rodents, mammals, animals)
SourceMesocricetus auratus (Golden hamster)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis;##Gram-negative bacteria: Escherichia coli, Salmonella serotype krefeld, Klebsiella oxytoca, Pseudomonas aeruginosa.##Fungi: Candida albicans, Cryptococcus neoformans.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot P81468
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8890190

Physicochemical Properties

Residues33
SequenceVTCFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ
Molecular Weight3821.437
Grand Average of Hydropathy-0.2
Isoelectric Point8.672
Charge at pH 7.42.37
Secondary StructureHelix: 0.273, Turn: 0.182, Sheet: 0.091
Instability Index42.391
Aromaticity0.121

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