Basic Information

IDDRAMP03408
SequenceVTCFCRRRGCASRERHIGYCRFGNTIYRLCCRR
Length33
NameNeutrophil defensin 1 (HANP-1; alpha-defensin; Rodents, mammals, animals)
SourceMesocricetus auratus (Golden hamster)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis;##Gram-negative bacteria: Escherichia coli, Salmonella serotype krefeld, Klebsiella oxytoca, Pseudomonas aeruginosa.##Fungi: Candida albicans, Cryptococcus neoformans.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot P81465
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8890190

Physicochemical Properties

Residues33
SequenceVTCFCRRRGCASRERHIGYCRFGNTIYRLCCRR
Molecular Weight4013.715
Grand Average of Hydropathy-0.524
Isoelectric Point10.196
Charge at pH 7.47.409
Secondary StructureHelix: 0.242, Turn: 0.152, Sheet: 0.091
Instability Index68.77
Aromaticity0.121

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