Basic Information
| ID | DRAMP03595 |
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| Sequence | ATCYCRTGRCATRESLSGVCEISGRLYRLCCR |
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| Length | 32 |
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| Name | Human defensin-5 (HD-5; Defensin, alpha 5; Human, mammals, animals) |
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| Source | Homo sapiens (Human) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral(SARS-CoV-2) |
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| Pathogen | [Ref.34206990]Virus:SARS-CoV-2:inhibition of infection in HEK293T-hACE2 cells(60% inhibition at 12.5 μg/mL (3.45 μM));SARS-CoV-2 variant P.1:inhibition of infection in HeLa-hACE2 cells(72% inbibition at 50 μg/mL);SARS-CoV-2 variant B.1.1.7:inhibition of infection in HeLa-hACE2 cells(32% inbibition at 50 μg/mL).##Gram-negative bacteria: Escherichia coli ATCC 8739 (vLD50=2.5±0.3 µg/ml), E. coli ATCC 25922 (vLD50=2.1±0.9 µg/ml), Enterobacter aerogenes ATCC 13048 (vLD50=5.5±0.5 µg/ml);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (vLD50=6.3±0.5 µg/ml), S. aureus ATCC 29213 (vLD50=3.2±0.3 µg/ml), Bacillus cereus ATCC 10876 (vLD50<0.31 µg/ml).(Ref.2)##NOTE: vLD50, virtual lethal doses (vLDs), equivalent to conventional 50% lethal doses (LD50s). |
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| Hemolytic Activity | [Ref.26206286] It has 0% hemolysis at 100μM against human red blood cells. |
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| Cytotoxicity | [Ref.34206990]No cytotoxicity on HEK293T cells up to 50 μg/mL. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
Q01523, A0JDY6, Q3KNV2 |
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| PDB |
1ZMP resolved by X-ray. |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 34206990, 12021776, 15616305, 26206286 |
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