Basic Information

IDDRAMP03422
SequenceACYCRIGACVSGERLTGACGLNGRIYRLCCR
Length31
NameNeutrophil antibiotic peptide NP-4 (RatNP-4; Rodents, mammals, animals)
SourceRattus norvegicus (Rat)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral, Antifungal
PathogenGram-positive bacterium: Staphylococcus aureus 502A (MIC=50 µg/ml);##Gram-negative bacteria: Escherichia coli ML-35, Acinetobacter calcoaceticus (MIC=50 µg/ml).Fungi: Cryptococcus neoformans (MIC=10 µg/ml), Candida albicans.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot Q62714
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID2543629, 7594610

Physicochemical Properties

Residues31
SequenceACYCRIGACVSGERLTGACGLNGRIYRLCCR
Molecular Weight3338.955
Grand Average of Hydropathy0.303
Isoelectric Point8.962
Charge at pH 7.43.457
Secondary StructureHelix: 0.258, Turn: 0.226, Sheet: 0.226
Instability Index28.816
Aromaticity0.065

Similar Structure Search

Candidates based on structure

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