Basic Information

IDDRAMP03409
SequenceCFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ
Length31
NameNeutrophil defensin 2 (HANP-2; alpha-defensin; Rodents, mammals, animals)
SourceMesocricetus auratus (Golden hamster)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis;##Gram-negative bacteria: Escherichia coli, Salmonella serotype krefeld, Klebsiella oxytoca, Pseudomonas aeruginosa.##Fungi: Candida albicans, Cryptococcus neoformans.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationCyclization(Cys1 and Cys29).
C-terminal ModificationFree
Linear/Cyclic/BranchedCyclic
Uniprot P81466
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8890190

Physicochemical Properties

Residues31
SequenceCFCKRPVCDSGETQIGYCRLGNTFYRLCCRQ
Molecular Weight3621.202
Grand Average of Hydropathy-0.326
Isoelectric Point8.674
Charge at pH 7.42.404
Secondary StructureHelix: 0.258, Turn: 0.194, Sheet: 0.097
Instability Index47.22
Aromaticity0.129

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.