Basic Information

IDDRAMP03644
SequenceRVKRVWPLVIRTVIAGYNLYRAIKKK
Length26
NameCathelicidin-1 (CATH-1; Fowlicidin-1; Birds, animals)
SourceGallus gallus (Chicken)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Cytolytic
Pathogen[Ref.16326712]Gram-negative bacteria: [No NaCl]Escherichia coli 25922 (MIC=1.59 µM), Escherichia coli O157:H7 700728 (MIC=0.80 µM), Salmonella typhimurium 14028 (MIC=0.80 µM), Salmonella typhimurium DT104 700408 (MIC=0.40 µM), Klebsiella pneumoniae 13883 (MIC=0.40 µM), Pseudomonas aeruginosa 27853 (MIC=3.18 µM);##[100mM NaCl]Escherichia coli 25922 (MIC=1.59 µM), Escherichia coli O157:H7 700728 (MIC=0.80 µM), Salmonella typhimurium 14028 (MIC=1.59 µM), Salmonella typhimurium DT104 700408 (MIC=1.59 µM), Klebsiella pneumoniae 13883 (MIC=0.80 µM), Pseudomonas aeruginosa 27853 (MIC=3.18 µM);##Gram-positive bacteria: Listeria monocytogenes 19115 (MIC=0.80 µM), Staphylococcus aureus 25923 (MIC=0.80 µM), Staphylococcus aureus (MRSA) BAA-39 (MIC=0.40 µM), Staphylococcus aureus (MRSA) 43300 (MIC=0.40 µM);##[100mM NaCl]Listeria monocytogenes 19115 (MIC=1.59 µM), Staphylococcus aureus 25923 (MIC=0.80 µM), Staphylococcus aureus (MRSA) BAA-39 (MIC=0.80 µM), Staphylococcus aureus (MRSA) 43300 (MIC=0.40 µM)
Hemolytic Activity[Ref.16326712]80% hemolytic activity at 10 μM against human erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot Q6QLQ5, Q2IAM1
PDB 2AMN
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16326712, 16817888

Physicochemical Properties

Residues26
SequenceRVKRVWPLVIRTVIAGYNLYRAIKKK
Molecular Weight3141.844
Grand Average of Hydropathy-0.069
Isoelectric Point11.604
Charge at pH 7.47.542
Secondary StructureHelix: 0.462, Turn: 0.115, Sheet: 0.154
Instability Index8.012
Aromaticity0.115

Similar Structure Search

Candidates based on structure

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