Basic Information

IDDRAMP03920
SequenceKWKLFKKIEKVGQGIGAVLKVLTTGL
Length26
NameCecropin A (1-8)-melittin (1-13)hybrid peptide
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.7 µM), Staphylococcus aureus Cowan 1 (MIC=2 µM), Streptococcus pyogenes (MIC=1 µM);##Gram-negative bacteria: Escherichia coli D21 (MIC=0.5 µM), Pseudomonas aeruginosa OT97 (MIC=1 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID1733777

Physicochemical Properties

Residues26
SequenceKWKLFKKIEKVGQGIGAVLKVLTTGL
Molecular Weight2855.506
Grand Average of Hydropathy0.273
Isoelectric Point10.302
Charge at pH 7.44.544
Secondary StructureHelix: 0.423, Turn: 0.154, Sheet: 0.231
Instability Index-8.654
Aromaticity0.077

Similar Structure Search

Candidates based on structure

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