Basic Information

IDDRAMP01650
SequenceALWKNMLKGIGKLAGQAALGAVKTLVGAE
Length29
NameDermaseptin-B3 (Dermaseptin BIII; Frogs, amphibians, animals)
SourcePhyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacteria: Pseudomonas aeruginosa CIP A22 (MIC=2.3 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=5 µM), Escherichia coli ATCC 25922 (MIC=2.6 µM), E. coli 54127 (MIC=2.3 µM);##Gram-positive bacterium: Staphylococcus aureus ATCC 25293 (MIC=1.3 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.9614066]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot P81485
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID9614066

Physicochemical Properties

Residues29
SequenceALWKNMLKGIGKLAGQAALGAVKTLVGAE
Molecular Weight2909.492
Grand Average of Hydropathy0.514
Isoelectric Point10.002
Charge at pH 7.42.601
Secondary StructureHelix: 0.310, Turn: 0.207, Sheet: 0.448
Instability Index-6.593
Aromaticity0.034

Similar Structure Search

Candidates based on structure

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