Basic Information

IDDRAMP01456
SequenceGLFSILKGVGKIALKGLAKNMGKMGLDLVSCKISKEC
Length37
NameEsculentin-2PLa (Frogs, amphibians, animals)
SourceRana palustris (Pickerel frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli (MIC=1 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=10 µM).##Yeast: Candida albicans (MIC=49 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys31 and Cys37)
Linear/Cyclic/BranchedCyclic
Uniprot A7WNV5, D3UA57
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11087945

Physicochemical Properties

Residues37
SequenceGLFSILKGVGKIALKGLAKNMGKMGLDLVSCKISKEC
Molecular Weight3851.753
Grand Average of Hydropathy0.468
Isoelectric Point9.7
Charge at pH 7.44.492
Secondary StructureHelix: 0.324, Turn: 0.270, Sheet: 0.297
Instability Index23.781
Aromaticity0.027

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