Basic Information

IDDRAMP01480
SequenceGFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC
Length37
NameEsculentin-2CPa (Frogs, amphibians, animals)
SourceLithobates capito (North American New World frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 µM);##Yeast: Candida albicans (MIC=25 µM)
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys31 and Cys37)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19635516

Physicochemical Properties

Residues37
SequenceGFFSLIKGVAKIATKGLAKNLGKMGLDLVGCKISKEC
Molecular Weight3839.678
Grand Average of Hydropathy0.441
Isoelectric Point9.7
Charge at pH 7.44.492
Secondary StructureHelix: 0.324, Turn: 0.243, Sheet: 0.270
Instability Index14.354
Aromaticity0.054

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