Basic Information

IDDRAMP01484
SequenceGIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC
Length37
NameEsculentin-2ISa (Frogs, amphibians, animals)
SourceOdorrana ishikawae (Japanese Endangered frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli (MC=12.5 µM);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 µM), Staphylococcus aureus (MRSA) (MIC=25 µM), Bacillus subtilis (MIC=6.3 µM).##Yeast: Candida albicans (MIC=100 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys31 and Cys37)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID21193000

Physicochemical Properties

Residues37
SequenceGIFSLIKGAAKLITKTVAKEAGKTGLELMACKVTNQC
Molecular Weight3837.617
Grand Average of Hydropathy0.357
Isoelectric Point9.514
Charge at pH 7.43.496
Secondary StructureHelix: 0.270, Turn: 0.162, Sheet: 0.324
Instability Index-3.849
Aromaticity0.027

Similar Structure Search

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