Basic Information

IDDRAMP01516
SequenceGLFSILRGAAKFASKGLGKDLTKLGVDLVACKISKQC
Length37
NameEsculentin-2B (Frogs, amphibians, animals)
SourceRana berlandieri (Rio Grande leopard frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=1 μM);##Gram-negative bacterium: Escherichia coli (MIC=1 μM).##Yeast: Candida albicans (MIC=29 μM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization of a C-terminal Cys residue (forming a disulfide bond)
Linear/Cyclic/BranchedCyclic
Uniprot P82839
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10651828

Physicochemical Properties

Residues37
SequenceGLFSILRGAAKFASKGLGKDLTKLGVDLVACKISKQC
Molecular Weight3837.599
Grand Average of Hydropathy0.392
Isoelectric Point9.787
Charge at pH 7.44.494
Secondary StructureHelix: 0.324, Turn: 0.216, Sheet: 0.270
Instability Index18.538
Aromaticity0.054

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