Basic Information

IDDRAMP01497
SequenceGLFSKFAGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC
Length46
NameEsculentin-1-OA5 (Frogs, amphibians, animals)
SourceOdorrana andersonii (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.4 µg/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=1.7 µg/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=3.4 µg/mL).##Yeast: Candida albicans ATCC 2002 (MIC=1.7 µg/mL).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.22029824]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues46
SequenceGLFSKFAGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC
Molecular Weight4831.855
Grand Average of Hydropathy0.465
Isoelectric Point9.836
Charge at pH 7.45.527
Secondary StructureHelix: 0.370, Turn: 0.239, Sheet: 0.130
Instability Index-8.552
Aromaticity0.065

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.