Basic Information

IDDRAMP01474
SequenceGIFSKINKKKAKTGLFNIIKTVGKEAGMDVIRAGIDTISCKIKGEC
Length46
NameEsculentin-1ARa (Frogs, amphibians, animals)
SourceRana areolata (crawfish frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.12429503]Gram-negative bacterium: Escherichia coli (MIC=2 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=13 µM).
Hemolytic Activity[Ref:12429503] HC50=180 µM against human erythrocytes
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12429503

Physicochemical Properties

Residues46
SequenceGIFSKINKKKAKTGLFNIIKTVGKEAGMDVIRAGIDTISCKIKGEC
Molecular Weight4925.877
Grand Average of Hydropathy-0.013
Isoelectric Point9.762
Charge at pH 7.45.489
Secondary StructureHelix: 0.283, Turn: 0.217, Sheet: 0.152
Instability Index17.759
Aromaticity0.043

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