Basic Information

IDDRAMP01493
SequenceGLFSKFVGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC
Length46
NameEsculentin-1-OA1 (Frogs, amphibians, animals)
SourceOdorrana andersonii (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Bacillus pyocyaneus CMCCB 10104 (MIC=1.2 µg/mL), Staphylococcus aureus ATCC 25923 (MIC=1.2 µg/mL).##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.2 µg/mL).##Yeast: Candida albicans ATCC 2002 (MIC=2.4 µg/mL).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues46
SequenceGLFSKFVGKGIKNFLIKGVKHIGKEVGMDVIRVGIDVAGCKIKGVC
Molecular Weight4859.908
Grand Average of Hydropathy0.517
Isoelectric Point9.836
Charge at pH 7.45.527
Secondary StructureHelix: 0.391, Turn: 0.239, Sheet: 0.109
Instability Index-10.398
Aromaticity0.065

Similar Structure Search

Candidates based on structure

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