Basic Information

IDDRAMP01482
SequenceGIFSKFAGKGIKNLLVKGVKNIGKEVGMDVIRTGIDIAGCKIKGEC
Length46
NameEsculentin-1ISa (Frogs, amphibians, animals)
SourceOdorrana ishikawae (Japanese Endangered frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacterium: Escherichia coli (MC=6.3 µM);##Gram-positive bacteria: Staphylococcus aureus (MIC=3.1 µM), Staphylococcus aureus (MRSA) (MIC=25 µM), Bacillus subtilis (MIC=25 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID21193000

Physicochemical Properties

Residues46
SequenceGIFSKFAGKGIKNLLVKGVKNIGKEVGMDVIRTGIDIAGCKIKGEC
Molecular Weight4806.758
Grand Average of Hydropathy0.222
Isoelectric Point9.628
Charge at pH 7.44.492
Secondary StructureHelix: 0.326, Turn: 0.261, Sheet: 0.152
Instability Index2.002
Aromaticity0.043

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