Basic Information

IDDRAMP01461
SequenceGLFSKFAGKGIKNMIIKGIKGIGKEVGMDVIRTGIDVAGCKIKGEC
Length46
NameEsculentin-1S (Frogs, amphibians, animals)
SourceOdorrana schmackeri (piebald odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=3 µM);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=1.7 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16427248

Physicochemical Properties

Residues46
SequenceGLFSKFAGKGIKNMIIKGIKGIGKEVGMDVIRTGIDVAGCKIKGEC
Molecular Weight4781.772
Grand Average of Hydropathy0.254
Isoelectric Point9.628
Charge at pH 7.44.492
Secondary StructureHelix: 0.304, Turn: 0.261, Sheet: 0.152
Instability Index-13.68
Aromaticity0.043

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