Basic Information

IDDRAMP01486
SequenceGLFSKFAGKGIKNLIFKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC
Length46
NameEsculentin-1GRa (Frogs, amphibians, animals)
SourceRana grahami (Odorrana andersonii)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli (MIC=6 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 µM).##Yeast: Candida albicans (MIC>50 µM).
Hemolytic Activity[Ref.16621155] LC50=210 μM against human erythrocytes.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16621155

Physicochemical Properties

Residues46
SequenceGLFSKFAGKGIKNLIFKGVKHIGKEVGMDVIRTGIDVAGCKIKGEC
Molecular Weight4863.811
Grand Average of Hydropathy0.191
Isoelectric Point9.628
Charge at pH 7.44.528
Secondary StructureHelix: 0.326, Turn: 0.239, Sheet: 0.152
Instability Index1.207
Aromaticity0.065

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