Basic Information

IDDRAMP01502
SequenceGIFSKISGKAIKNLFIKGAENVGKHVGIDVVRTGIDVVGCKIKGEC
Length46
NameEsculentin-1-OR4 (Frogs, amphibians, animals)
SourceOdorrana rotodora (Chinese odorous frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli ATCC 25922 (MIC=8.6 µg/mL);##Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=8.6 µg/mL), Bacillus pyocyaneus CMCCB 10104 (MIC=8.6 µg/mL).##Yeast: Candida albicans ATCC 2002 (MIC=8.6 µg/mL).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.22029824]No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22029824

Physicochemical Properties

Residues46
SequenceGIFSKISGKAIKNLFIKGAENVGKHVGIDVVRTGIDVVGCKIKGEC
Molecular Weight4799.659
Grand Average of Hydropathy0.287
Isoelectric Point9.448
Charge at pH 7.43.531
Secondary StructureHelix: 0.348, Turn: 0.261, Sheet: 0.109
Instability Index-13.68
Aromaticity0.043

Similar Structure Search

Candidates based on structure

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