Basic Information

IDDRAMP01471
SequenceGLFPKINKKKAKTGVFNIIKTVGKEAGMDLIRTGIDTIGCKIKGEC
Length46
NameEsculentin-1PLa (Frogs, amphibians, animals)
SourceRana palustris (North American pickerel frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacterium: Escherichia coli (MIC=1 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=12 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11087945

Physicochemical Properties

Residues46
SequenceGLFPKINKKKAKTGVFNIIKTVGKEAGMDLIRTGIDTIGCKIKGEC
Molecular Weight4935.915
Grand Average of Hydropathy-0.091
Isoelectric Point9.762
Charge at pH 7.45.489
Secondary StructureHelix: 0.283, Turn: 0.217, Sheet: 0.152
Instability Index14.859
Aromaticity0.043

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