Basic Information

IDDRAMP01475
SequenceGLFPKFNKKKVKTGIFDIIKTVGKEAGMDVLRTGIDVIGCKIKGEC
Length46
NameEsculentin-1ARb (Frogs, amphibians, animals)
SourceRana areolata (crawfish frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.12429503]Gram-negative bacterium: Escherichia coli (MIC=3 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=60 µM).
Hemolytic Activity[Ref:12429503] HC50=120 µM against human erythrocytes
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12429503

Physicochemical Properties

Residues46
SequenceGLFPKFNKKKVKTGIFDIIKTVGKEAGMDVLRTGIDVIGCKIKGEC
Molecular Weight4996.996
Grand Average of Hydropathy0.03
Isoelectric Point9.568
Charge at pH 7.44.489
Secondary StructureHelix: 0.326, Turn: 0.196, Sheet: 0.130
Instability Index12.972
Aromaticity0.065

Similar Structure Search

Candidates based on structure

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