Basic Information

IDDRAMP01457
SequenceGIFSKFAGKGIKDLIIKGVKGIAKEAGMDVIRTGIDIAGCKIKGEC
Length46
NameEsculentin-1V (Frogs, amphibians, animals)
SourceOdorrana hainanensis (Chinese frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacterium: Staphylococcus aureus FDA 209P (MIC=4.9 µM);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MIC=3.2 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID16427248

Physicochemical Properties

Residues46
SequenceGIFSKFAGKGIKDLIIKGVKGIAKEAGMDVIRTGIDIAGCKIKGEC
Molecular Weight4750.691
Grand Average of Hydropathy0.307
Isoelectric Point9.393
Charge at pH 7.43.492
Secondary StructureHelix: 0.304, Turn: 0.217, Sheet: 0.174
Instability Index-8.77
Aromaticity0.043

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