Basic Information

IDDRAMP01479
SequenceGLFSKLNKKKIKSGLIKIIKTAGKEAGLEALRTGIDVIGCKIKGEC
Length46
NameEsculentin-1CPa (Frogs, amphibians, animals)
SourceLithobates capito (North American New World frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.19635516]Gram-negative bacterium: Escherichia coli (MIC=25 µM);##Gram-positive bacterium: Staphylococcus aureus (MIC=50 µM);##Yeast: Candida albicans (MIC=25 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys40 and Cys46)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19635516

Physicochemical Properties

Residues46
SequenceGLFSKLNKKKIKSGLIKIIKTAGKEAGLEALRTGIDVIGCKIKGEC
Molecular Weight4871.893
Grand Average of Hydropathy0.024
Isoelectric Point9.866
Charge at pH 7.46.487
Secondary StructureHelix: 0.304, Turn: 0.217, Sheet: 0.239
Instability Index4.883
Aromaticity0.022

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