Basic Information

IDDRAMP01517
SequenceGFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC
Length37
NameEsculentin-2P (Frogs, amphibians, animals)
SourceRana pipiens (northern leopard frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram-, Antiviral
Pathogen[Ref.10651828]Gram-negative bacterium: Escherichia coli (MIC=10 μM).##[Ref.11601906]Virus:##Frog Virus 3: 90% inhibition at 500 µM;##Channel Catfish Virus: 90% inhibition at 50 µM.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found in the reference(s) presented
N-terminal ModificationFree
C-terminal ModificationCyclization of a C-terminal Cys residue (forming a disulfide bond)
Linear/Cyclic/BranchedCyclic
Uniprot P82846
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID11601906, 10651828

Physicochemical Properties

Residues37
SequenceGFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC
Molecular Weight3870.591
Grand Average of Hydropathy0.357
Isoelectric Point10.208
Charge at pH 7.45.496
Secondary StructureHelix: 0.324, Turn: 0.270, Sheet: 0.216
Instability Index21.984
Aromaticity0.081

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