Basic Information

IDDRAMP03927
SequenceKWKLFKKIGAVLKVL
Length15
NameCecropin A (1-7)-melittin (2-9)hybrid peptide
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacteria: Escherichia coli D21 (MIC=1 µM), Pseudomonas aeruginosa OT97 (MIC=4 µM);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.5 µM), Bacillus megaterium Bm11 (MIC=0.7 µM), Staphylococcus aureus Cowan 1 (MIC=2 µM), Streptococcus pyogenes (MIC=0.5 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB 2JMY
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID1733777, 17397158

Physicochemical Properties

Residues15
SequenceKWKLFKKIGAVLKVL
Molecular Weight1771.282
Grand Average of Hydropathy0.54
Isoelectric Point10.602
Charge at pH 7.44.545
Secondary StructureHelix: 0.533, Turn: 0.067, Sheet: 0.267
Instability Index-28.987
Aromaticity0.133

Similar Structure Search

Candidates based on structure

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