Basic Information

IDDRAMP18536
SequenceKWKSFLKTFKSAKKTVLHTLLKAISS
Length26
NameA20L (V13KL peptide derivative)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.17158938]Gram-negative bacteria: Pseudomonas aeruginosa PAO1(MIC=7.8 μg/ml), Pseudomonas aeruginosa WR5 (MIC=31.3 μg/ml), Pseudomonas aeruginosa PAK (MIC=31.3 μg/ml), Pseudomonas aeruginosa PA14 (MIC=15.6 μg/ml), Pseudomonas aeruginosa M2 (MIC=15.6 μg/ml), Pseudomonas aeruginosa CP204 (MIC=7.7 μg/ml), The geometric mean of MIC values above six Gram-negative strains (MIC=15.6 μg/ml)
Hemolytic Activity[Ref.17158938]MHC=31.3 μg/ml against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID17158938

Physicochemical Properties

Residues26
SequenceKWKSFLKTFKSAKKTVLHTLLKAISS
Molecular Weight2991.614
Grand Average of Hydropathy-0.138
Isoelectric Point10.778
Charge at pH 7.46.577
Secondary StructureHelix: 0.346, Turn: 0.154, Sheet: 0.231
Instability Index6.558
Aromaticity0.115

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