Basic Information

IDDRAMP18566
SequenceVNWKKSLGKSIKVVK
Length15
NameLL-IIIs-1 (lasioglossin III peptide derivative)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal
Pathogen[Ref.22526241]Gram-positive bacteria: Micrococcus luteus (MIC=0.7 μM), Bacillus cereus (MIC=0.8 μM), Staphylococcus aureus (MIC=12.5 μM);##Gram-negative bacteria: Escherichia coli (MIC=4.4 μM), Pseudomonas aeruginosa (MIC=78.7 μM);##Fungi: Candida albicans (MIC=100 μM)
Hemolytic Activity[Ref.22526241]LC50=31.3 μM against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22526241

Physicochemical Properties

Residues15
SequenceVNWKKSLGKSIKVVK
Molecular Weight1714.103
Grand Average of Hydropathy-0.333
Isoelectric Point10.602
Charge at pH 7.44.511
Secondary StructureHelix: 0.400, Turn: 0.267, Sheet: 0.067
Instability Index-16.48
Aromaticity0.067

Similar Structure Search

Candidates based on structure

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