Basic Information
| ID | DRAMP21400 |
|---|
| Sequence | CGIYRSLKLIKSLVLIK |
|---|
| Length | 17 |
|---|
| Name | NBC2253 (De Novo Synthesis) |
|---|
| Source | synthetic construct |
|---|
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
|---|
| Pathogen | [Ref.31119600] Gram-positive bacteria:MRSA(MIC=6.7 ± 0.02µM);##Gram-negative bacteria:Escherichia coli O157:H7(MIC=25 ± 0.03µM) |
|---|
| Hemolytic Activity | [Ref.31119600] No hemolytic activity against bovine blood cells |
|---|
| Cytotoxicity | [Ref.31119600] The cell viability of Vero ATCC CCL 1-81 cells induced by NBC2253 is 87.8%, 66.4%, 62.2%, 69.1% and 68.8% at peptide concentrations of 1.2, 3.7, 11.1, 33.3 and 100 μM. |
|---|
| N-terminal Modification | The sulfhydryl side chain of the cysteine residue was conjugated to AuNC(previously modified with SPDP) via a disulfide bond. |
|---|
| C-terminal Modification | Free |
|---|
| Linear/Cyclic/Branched | Linear |
|---|
| Uniprot |
|
|---|
| PDB |
|
|---|
| 3D View | |
|---|
| PDB Download | Download PDB Predicted by Alphafold2 |
|---|
| PubMed ID | 31119600 |
|---|
