Basic Information
| ID | DRAMP21401 |
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| Sequence | CALKLTKAKRLVRKIGF |
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| Length | 17 |
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| Name | NBC2254 (De Novo Synthesis) |
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| Source | synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.31119600] Gram-positive bacteria:MRSA(MIC=73 ± 0.02µM);##Gram-negative bacteria:Escherichia coli O157:H7(MIC=3.5 ± 0.05µM) |
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| Hemolytic Activity | [Ref.31119600] No hemolytic activity against bovine blood cells |
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| Cytotoxicity | [Ref.31119600] The cell viability of Vero ATCC CCL 1-81 cells induced by NBC2254 is 93.7%, 90.1%, 89.5%, 95.9% and 78.6% at peptide concentrations of 1.2, 3.7, 11.1, 33.3 and 100 μM. |
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| N-terminal Modification | The sulfhydryl side chain of the cysteine residue was conjugated to AuNC(previously modified with SPDP) via a disulfide bond. |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 31119600 |
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