Basic Information

IDDRAMP02403
SequenceGILKKFMLHRGTKVYKMRTLSKRSH
Length25
NameAntimicrobial peptide scolopin-2
SourceScolopendra mutilans (Chinese red-headed centipede) (Scolopendrasubspinipes mutilans)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.19716842]Gram-negative bacteria: Escherichia coli standard and drug-resistant strains (MIC=5.0 µg/ml);##Gram-positive bacteria: Staphylococcus aureus standard strain (MIC=0.5 µg/ml), S. aureus drug-resistant strain (MIC=1.0 µg/ml), Bacillus dysenteriae standard strain (MIC=2.5 µg/ml), B. dysenteriae drug-resistant strain (MIC=5.0 µg/ml);##Yeast: Candida albicans (MIC=7.5 µg/ml).
Hemolytic Activity[Ref.19716842]32 ± 7% hemolytic activity at 50 μg/ml against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P0CH49
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID19716842

Physicochemical Properties

Residues25
SequenceGILKKFMLHRGTKVYKMRTLSKRSH
Molecular Weight3016.678
Grand Average of Hydropathy-0.712
Isoelectric Point11.764
Charge at pH 7.47.616
Secondary StructureHelix: 0.280, Turn: 0.160, Sheet: 0.200
Instability Index37.948
Aromaticity0.08

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