Basic Information
| ID | DRAMP20968 |
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| Sequence | MMRVMRRKTKVIWEKKDFIGLYSID |
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| Length | 25 |
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| Name | Catesbeianin-1 (Ranidae, Anura, Amphibia, Animals) |
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| Source | Lithobates catesbeiana (American bullfrog) (Rana catesbeiana) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.28258530] Gram-positive bacteria : Staphylococcus aureus ATCC 25923 (MIC=3.1 μg/ml;MBC=6.3 μg/ml), B. subtilis ATCC6633 (MIC=25 μg/ml;MBC=50 μg/ml), Streptococcus suis CVCC606 (MIC=3.1 μg/ml;MBC=12.5 μg/ml), Listeria monocytogenes ATCC19115 (MIC=12.5 μg/ml;MBC=25 μg/ml);##Gram-negative bacteria : Escherichia coli ATCC 25922 (MIC=3.1 μg/ml;MBC=12.5 μg/ml), Pseudomonas aeruginosa ATCC227853 (MIC=12.5 μg/ml;MBC=25 μg/ml), Salmonella spp. CVCC 3377 (MIC=6.3 μg/ml;MBC=25 μg/ml), Klebsiella pneumoniae H507 (MIC=25 μg/ml;MBC=100 μg/ml) |
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| Hemolytic Activity | [Ref.28258530] 0% hemolysis at 0 μg/ml , hemolysis 3% at 25 μg/ml , 7% hemolysis at 50 μg/ml , 8% hemolysis at 100 μg/ml , 35% hemolysis at 200 μg/ml , 50% hemolysis at 300 μg/ml , 85% hemolysis at 400 μg/ml , 95% hemolysis at 500 μg/ml against human red blood cells |
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| Cytotoxicity | [Ref.28258530] The cell viability of HEK293T cells is 102%, 103%, 103%, 100%, 98% and 85% at peptide concentrations of 0, 20, 40, 60, 80 and 100 μg/ml. ##The cell viability of HL-7200 cells is 107%, 106%, 99%, 95% and 88% at peptide concentrations of 0, |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
C5IAX4 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28258530 |
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