Basic Information

IDDRAMP20888
SequenceKLIWILSKTIPAGKNLFYKI
Length20
NameNCP-3 (CTX-1 peptide derivative)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29364903] Gram-positive bacteria: Methicillin-resistant Staphylococcus aureus ATCC 43300 (MBC=6.3 μg/ml), Staphylococcus aureus ATCC 22953 (MBC=1.6 μg/ml), Enterococcus hirae ATCC 10541 (MBC=1.6 μg/ml), Streptococcus agalactiae ATCC 13813 (MBC=1.6 μg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MBC=12.5 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MBC=12.5 μg/ml), Acinetobacter baumannii (herpetological, cloacal) (MBC=1.6 μg/ml), Acinetobacter baumannii (ornithological, cloacal) (MBC=6.3 μg/ml), Acinetobacter baumannii (human, urinary) (MBC=1.6 μg/ml), Klebsiella pneumoniae subsp. pneumoniae (herpetological, cloacal) (MBC=50 μg/ml), Enterobacter cloacae (herpetological, cloacal) (MBC=25 μg/ml), Burkholderia cepacia ATCC 17759 (MBC=50 μg/ml), Moraxella catarrhalis ATCC 25238 (MBC=1.6 μg/ml);##Fungi: Candida albicans ATCC 10231 (MBC=12.5 μg/mL), Candida glabrata ATCC 90030 (MBC=50 μg/mL), Malassezia pachydermatis DSMZ 6172 (MBC=6.3 μg/mL).
Hemolytic Activity[Ref.29364903] 3% haemolysis at 12.5 μg/ml, 9% haemolysis at 100.0 μg/ml against sheep red blood cells
Cytotoxicity[Ref.29364903] The cell death rate of Madin-Darby Bovine Kidney(MDBK) cells is 3 % and 7% at peptide concentrations of 12.5 and 100 μg/ml
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29364903

Physicochemical Properties

Residues20
SequenceKLIWILSKTIPAGKNLFYKI
Molecular Weight2346.893
Grand Average of Hydropathy0.46
Isoelectric Point10.177
Charge at pH 7.43.545
Secondary StructureHelix: 0.500, Turn: 0.200, Sheet: 0.200
Instability Index30.885
Aromaticity0.15

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.