Basic Information

IDDRAMP18637
SequenceKLILILSKTIPAGKNLFYKI
Length20
NameNCP-3b (CTX-1 peptide derivative)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29364903] Gram-positive bacteria: Methicillin-resistant Staphylococcus aureus ATCC 43300 (MBC=6.3 μg/ml), Staphylococcus aureus ATCC 22953 (MBC=50 μg/ml), Enterococcus hirae ATCC 10541 (MBC=12.5 μg/ml), Streptococcus agalactiae ATCC 13813 (MBC=12.5 μg/ml);##Gram-negative bacterium: Escherichia coli ATCC 25922 (MBC=12.5 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MBC=25 μg/ml), Acinetobacter baumannii (ornithological, cloacal) (MBC=25 μg/ml), Acinetobacter baumannii (human, urinary) (MBC=25 μg/ml), Klebsiella pneumoniae subsp. pneumoniae (herpetological, cloacal) (MBC=25 μg/ml), Burkholderia cepacia ATCC 17759 (MBC=25 μg/ml), Moraxella catarrhalis ATCC 25238 (MBC=12.5 μg/ml);##Fungi: Candida albicans ATCC 10231 (MBC=12.5 μg/mL), Candida glabrata ATCC 90030 (MBC=100 μg/mL), Malassezia pachydermatis DSMZ 6172 (MBC=25 μg/mL)
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29364903

Physicochemical Properties

Residues20
SequenceKLILILSKTIPAGKNLFYKI
Molecular Weight2273.841
Grand Average of Hydropathy0.695
Isoelectric Point10.177
Charge at pH 7.43.545
Secondary StructureHelix: 0.500, Turn: 0.200, Sheet: 0.250
Instability Index40.515
Aromaticity0.1

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.