Basic Information
| ID | DRAMP20887 |
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| Sequence | KLIPILSKTIPAGKNLFYKI |
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| Length | 20 |
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| Name | NCP-2 (CTX-1 peptide derivative) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.29364903] Gram-positive bacteria: Staphylococcus aureus ATCC 22953 (MBC=50 μg/ml), Streptococcus agalactiae ATCC 13813 (MBC=12.5 μg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MBC=12.5 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MBC=12.5 μg/ml), Acinetobacter baumannii (herpetological, cloacal) (MBC=1.6 μg/ml), Acinetobacter baumannii (ornithological, cloacal) (MBC=50 μg/ml), Acinetobacter baumannii (human, urinary) (MBC=1.6 μg/ml), Moraxella catarrhalis ATCC 25238 (MBC=1.6 μg/ml);##Fungi: Candida albicans ATCC 10231 (MBC=50 μg/mL), Malassezia pachydermatis DSMZ 6172 (MBC=6.3 μg/mL) |
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| Hemolytic Activity | [Ref.29364903] 2% haemolysis at 12.5 μg/ml, 8% haemolysis at 100.0 μg/ml against sheep red blood cells |
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| Cytotoxicity | [Ref.29364903] The cell death rate of Madin-Darby Bovine Kidney(MDBK) cells is 3 % and 5% at peptide concentrations of 12.5 and 100 μg/ml |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 29364903 |
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