Basic Information
| ID | DRAMP21014 |
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| Sequence | KILPGVCKKIMRPFLRRISKDILTGKK |
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| Length | 27 |
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| Name | NK-dpro (Derived from NK-2) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor |
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| Pathogen | [Ref.29043494]Gram-positive bacteria : Staphylococcus aureus (MIC=8 μM), Staphylococcus epidermidis (MIC=8 μM);##Gram-negative bacteria : Escherichia coli (MIC=8 μM), Pseudomonas aeruginosa (MIC=32 μM) |
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| Hemolytic Activity | [Ref.29043494] 0% hemolysis at 10 μg/ml , 2% hemolysis at 25 μg/ml , 3% hemolysis at 50 μg/ml , 4.5% hemolysis at 75 μg/ml , 10% hemolysis at 150 μg/ml , 20% hemolysis at 300 μg/ml against human red blood cells |
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| Cytotoxicity | [Ref.29043494] IC50 = 32.5 μM against NK-2. ##IC50 = 28.7 μM against EJ. ##IC50 = 9.6 μM against PC-3. ##IC50 = 39.6 μM against T24. ##IC50 = 48.4 μM against HL-60. ##The proliferation inhibition activity on K562 is not significant. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 29043494 |
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