Basic Information
| ID | DRAMP21013 |
|---|
| Sequence | KILRGVCKKIMRPFLRRISKDILTGKK |
|---|
| Length | 27 |
|---|
| Name | NK-pro (Derived from NK-2) |
|---|
| Source | Synthetic construct |
|---|
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antitumor |
|---|
| Pathogen | [Ref.29043494]Gram-positive bacteria : Staphylococcus aureus (MIC=4 μM), Staphylococcus epidermidis (MIC=4 μM);##Gram-negative bacteria : Escherichia coli (MIC=4 μM), Pseudomonas aeruginosa (MIC=16 μM) |
|---|
| Hemolytic Activity | [Ref.29043494] 0.3% hemolysis at 10 μg/ml , 2% hemolysis at 25 μg/ml , 5.5% hemolysis at 50 μg/ml , 8% hemolysis at 75 μg/ml , 15% hemolysis at 150 μg/ml , 28% hemolysis at 300 μg/ml against human red blood cells |
|---|
| Cytotoxicity | [Ref.29043494] IC50 = 43.7 μM against NK-2. ##IC50 = 23.3 μM against EJ. ##IC50 = 9.3 μM against PC-3. ##IC50 = 33.0 μM against T24. ##IC50 = 26.1 μM against HL-60. ####The proliferation inhibition activity on K562 is not significant. |
|---|
| N-terminal Modification | Free |
|---|
| C-terminal Modification | Amidation |
|---|
| Linear/Cyclic/Branched | Linear |
|---|
| Uniprot |
|
|---|
| PDB |
|
|---|
| 3D View | |
|---|
| PDB Download | Download PDB Predicted by Alphafold2 |
|---|
| PubMed ID | 29043494 |
|---|
