Basic Information
| ID | DRAMP21616 |
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| Sequence | qqrkrkiwsilaplgttlvklvagig |
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| Length | 26 |
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| Name | DRIM |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.28921993] Gram-positive bacteria: Staphylococcus aureus (MIC = 32 μg/mL), Enterococcus faecalis (MIC = 32 μg/mL);##Gram-negative bacteria: Escherichia coli (MIC = 32 μg/mL), Pseudomonas aeruginosa (MIC = 64 μg/mL) |
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| Hemolytic Activity | [Ref.28921993] 60.5%, 98.0%, 95.1%, 99.0%, 97.9%, 96.3%, 98.8% and 98.2% hemolysis against human red blood cells at 5, 7.5, 10, 15, 20, 25, 30 and 40 μg/ml. |
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| Cytotoxicity | [Ref.28921993] The toxicity of DRIM toward HEK293 and HeLa cells is much less than nonaarginine (R9) by use of flow cytometry and the peptide doesn't show any cytotoxicity at 2 μM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28921993 |
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