| ID | DRAMP04083 |
|---|---|
| Sequence | GIGKFLKKAKKFGKAFVKILKK |
| Length | 22 |
| Name | D-amino-acid pexiganan (MSI-214) |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=16 µg/ml), Enterococcus faecium ATCC 51559 (vancomycin resistant) (MIC=4 µg/ml), Enterococcus faecalis ATCC 29212 (MIC=16 µg/ml), Streptococcus bovis ATCC 49133 (MIC=4 µg/ml), Micrococcus luteus ATCC 4698 (MIC=2-4 µg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8-16 µg/ml), Proteus mirabilis ATCC 29245 (MIC>256 µg/ml), Serratia marcescens ATCC 8100 (MIC>256 µg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16-32 µg/ml). |
| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 10103181 |
Physicochemical Properties
| Residues | 22 |
|---|---|
| Sequence | GIGKFLKKAKKFGKAFVKILKK |
| Molecular Weight | 2478.159 |
| Grand Average of Hydropathy | -0.159 |
| Isoelectric Point | 10.903 |
| Charge at pH 7.4 | 8.535 |
| Secondary Structure | Helix: 0.364, Turn: 0.136, Sheet: 0.182 |
| Instability Index | -6.164 |
| Aromaticity | 0.136 |
