Basic Information

IDDRAMP04083
SequenceGIGKFLKKAKKFGKAFVKILKK
Length22
NameD-amino-acid pexiganan (MSI-214)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=16 µg/ml), Enterococcus faecium ATCC 51559 (vancomycin resistant) (MIC=4 µg/ml), Enterococcus faecalis ATCC 29212 (MIC=16 µg/ml), Streptococcus bovis ATCC 49133 (MIC=4 µg/ml), Micrococcus luteus ATCC 4698 (MIC=2-4 µg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8-16 µg/ml), Proteus mirabilis ATCC 29245 (MIC>256 µg/ml), Serratia marcescens ATCC 8100 (MIC>256 µg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16-32 µg/ml).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10103181

Physicochemical Properties

Residues22
SequenceGIGKFLKKAKKFGKAFVKILKK
Molecular Weight2478.159
Grand Average of Hydropathy-0.159
Isoelectric Point10.903
Charge at pH 7.48.535
Secondary StructureHelix: 0.364, Turn: 0.136, Sheet: 0.182
Instability Index-6.164
Aromaticity0.136

Similar Structure Search

Candidates based on structure

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