Basic Information

IDDRAMP20936
SequenceRVKRFKKFFRKIKKGFRKIFKKTKIFIG
Length28
NameΔPb-CATH1
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.28630199] Gram-positive bacteria: Staphylococcus aureus (ATCC 29213)(MIC>128 μg/ml); B. cereus ATCC 10876 (MIC=46 μg/ml);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=2 μg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=3 μg/ml), S. typhimurium ATCC 14028 (MIC=1.5 μg/ml)
Hemolytic Activity[Ref.28630199]1.4 ± 0.4% hemolysis at 8 μg/ml, 5.1 ± 0.5% hemolysis at 16 μg/ml, 7.3 ± 0.6% hemolysis at 32 μg/ml, 12.2 ± 0.7% hemolysis at 64 μg/ml against chicken red blood cells
Cytotoxicity[Ref.28630199] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID28630199

Physicochemical Properties

Residues28
SequenceRVKRFKKFFRKIKKGFRKIFKKTKIFIG
Molecular Weight3574.492
Grand Average of Hydropathy-0.696
Isoelectric Point12
Charge at pH 7.413.532
Secondary StructureHelix: 0.393, Turn: 0.071, Sheet: 0.000
Instability Index-5.639
Aromaticity0.214

Similar Structure Search

Candidates based on structure

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